The development of chronic kidney disease (CKD) and its progression to end-stage renal disease remains a significant source of reduced quality of life and premature mortality. In end-stage renal disease (ESRD), an individual’s kidneys permanently stop functioning, resulting in the necessity of long-term dialysis or a kidney transplant to survive. This course includes a complete overview of ESRD, its potential causes, and current treatments options for overall improved quality of life.